Reaction Details Report a problem with these data
Target
Cytochrome b
Ligand
BDBM192068
Substrate
n/a
Meas. Tech.
Cytochrome b Enzyme Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
2356±n/a nM
Comments
extracted
Citation
 Vincent, BM; Langlois, JB; Srinivas, R; Lancaster, AK; Scherz-Shouval, R; Whitesell, L; Tidor, B; Buchwald, SL; Lindquist, S A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance. Cell Chem Biol 23:978-991 (2016) [PubMed]  Article 
Target
Name:
Cytochrome b
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
43717.83
Organism:
Candida albicans (Yeast)
Description:
n/a
Residue:
387
Sequence:
MPTRKSNTYLSLVNSYLIDSPQPSSINYWWNLGSLLGLCLVIQIASGVFLAMHYSSNIELAFDSVEHIMRDVNAGWLIRYIHANGASFFFICMYLHIGKALYYGSYKQPRVMLWVIGVVIFILTMAIAFMGYCLVYGQMSHWGATVITNLLSAIPFIGNDIVPFIWGGFSVSNPTIQRFFALHFLLPFILAALVCMHLMALHVHGSSNPVGITGNIDRLPMHPYFIFKDLITVFVFLLIFSLFVFYSPNTLGHPDNYIPGNPMVTPPSIVPEWYLLPFYAILRSIPDKLGGVIAMFGAILILLSLPYTDRSIIRGNSFKVLSKLAFYLFVFNFILLGNLGQLHVEVPYIQLGQFATAYYFAHYIIVVPVISTLENILYYIGTQTRVK
  
Inhibitor
Name:
BDBM192068
Synonyms:
Inz-59
Type:
Small organic molecule
Emp. Form.:
C16H12F2N2O2
Mol. Mass.:
302.2755
SMILES:
COC(=O)Cn1nc(-c2c(F)cccc2F)c2ccccc12 |(13.8,-10.81,;12.3,-10.49,;11.82,-9.03,;12.85,-7.88,;10.31,-8.71,;9.84,-7.24,;10.74,-5.99,;9.84,-4.75,;10.31,-3.28,;9.28,-2.14,;7.78,-2.46,;9.76,-.68,;11.27,-.36,;12.3,-1.5,;11.82,-2.96,;12.85,-4.11,;8.37,-5.22,;7.04,-4.45,;5.71,-5.22,;5.71,-6.76,;7.04,-7.53,;8.37,-6.76,)|
Structure:
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