Reaction Details Report a problem with these data
Target
Cytochrome b
Ligand
BDBM192075
Substrate
n/a
Meas. Tech.
Cytochrome b Enzyme Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
1085±n/a nM
Comments
extracted
Citation
 Vincent, BM; Langlois, JB; Srinivas, R; Lancaster, AK; Scherz-Shouval, R; Whitesell, L; Tidor, B; Buchwald, SL; Lindquist, S A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance. Cell Chem Biol 23:978-991 (2016) [PubMed]  Article 
Target
Name:
Cytochrome b
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
43717.83
Organism:
Candida albicans (Yeast)
Description:
n/a
Residue:
387
Sequence:
MPTRKSNTYLSLVNSYLIDSPQPSSINYWWNLGSLLGLCLVIQIASGVFLAMHYSSNIELAFDSVEHIMRDVNAGWLIRYIHANGASFFFICMYLHIGKALYYGSYKQPRVMLWVIGVVIFILTMAIAFMGYCLVYGQMSHWGATVITNLLSAIPFIGNDIVPFIWGGFSVSNPTIQRFFALHFLLPFILAALVCMHLMALHVHGSSNPVGITGNIDRLPMHPYFIFKDLITVFVFLLIFSLFVFYSPNTLGHPDNYIPGNPMVTPPSIVPEWYLLPFYAILRSIPDKLGGVIAMFGAILILLSLPYTDRSIIRGNSFKVLSKLAFYLFVFNFILLGNLGQLHVEVPYIQLGQFATAYYFAHYIIVVPVISTLENILYYIGTQTRVK
  
Inhibitor
Name:
BDBM192075
Synonyms:
Inz-66
Type:
Small organic molecule
Emp. Form.:
C24H22N2O3
Mol. Mass.:
386.4431
SMILES:
COC(=O)Cn1nc(-c2cccc(OCc3ccccc3)c2C)c2ccccc12
Structure:
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