Reaction Details Report a problem with these data
Target
Cytochrome b
Ligand
BDBM192047
Substrate
n/a
Meas. Tech.
Cytochrome b Enzyme Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
>6.4e+4±n/a nM
Comments
extracted
Citation
 Vincent, BM; Langlois, JB; Srinivas, R; Lancaster, AK; Scherz-Shouval, R; Whitesell, L; Tidor, B; Buchwald, SL; Lindquist, S A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance. Cell Chem Biol 23:978-991 (2016) [PubMed]  Article 
Target
Name:
Cytochrome b
Synonyms:
COB | CYB_HUMAN | CYTB | MT-CYB | MTCYB
Type:
Protein
Mol. Mass.:
42724.13
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
380
Sequence:
MTPMRKTNPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRFFTFHFILPFIIAALATLHLLFLHETGSNNPLGITSHSDKITFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLKWA
  
Inhibitor
Name:
BDBM192047
Synonyms:
Inz-38
Type:
Small organic molecule
Emp. Form.:
C20H14F4N4
Mol. Mass.:
386.3456
SMILES:
Cc1cccc2c(nn(Cc3cnccn3)c12)-c1cc(ccc1F)C(F)(F)F
Structure:
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