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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM192208
Substrate
n/a
Meas. Tech.
Fluorescence Polarization (FP) Assay
Temperature
293.15±n/a K
Ki
6.7±n/a nM
Comments
extracted
Citation
 Doemling, A p53-Mdm2 antagonists US Patent  US9187441 Publication Date 11/17/2015 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM192208
Synonyms:
US9187441, 6Q
Type:
Small organic molecule
Emp. Form.:
C25H24ClF4N3O4
Mol. Mass.:
541.922
SMILES:
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1C(N(Cc1c(F)c(F)cc(F)c1F)C=O)C(=O)NC(C)(C)C
Structure:
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