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Target
Cholesteryl ester transfer protein
Ligand
BDBM192290
Substrate
n/a
Meas. Tech.
CETP Inhibition Assay
Temperature
310.15±n/a K
IC50
32±n/a nM
Comments
extracted
Citation
 Nakamura, T; Namiki, H; Terasaka, N; Shima, A; Hagihara, M; Iwase, N; Takata, K; Kikuchi, O; Tsuboike, K; Setoguchi, H; Yoneda, K; Sunamoto, H; Ito, K Substituted pyridine compound US Patent  US9187450 Publication Date 11/17/2015 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM192290
Synonyms:
US9187450, 39 | US9321747, 14
Type:
Small organic molecule
Emp. Form.:
C37H44F6N4O4
Mol. Mass.:
722.7601
SMILES:
CC1(C)C[C@H](O)c2c(C1)nc(C1CCN(CC1)c1ncc(OC[C@@H](O)CO)cn1)c([C@@H](F)c1ccc(cc1)C(F)(F)F)c2C1CCC(F)(F)CC1 |r|
Structure:
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