Reaction Details Report a problem with these data
Target
Geranylgeranyl pyrophosphate synthase BTS1 [Y107A,F108A]
Ligand
BDBM12578
Substrate
n/a
Meas. Tech.
Fluorescent Assay
IC50
7.1e+2± 3e+1 nM
Citation
 Teng, KH; Hsu, ET; Chang, YH; Lin, SW; Liang, PH Fluorescent Farnesyl Diphosphate Analogue: A Probe To Validate trans-Prenyltransferase Inhibitors. Biochemistry 55:4366-74 (2016) [PubMed]  Article 
Target
Name:
Geranylgeranyl pyrophosphate synthase BTS1 [Y107A,F108A]
Synonyms:
BTS1 | GGPPS_YEAST | Geranylgeranyl diphosphate synthase mutant (GGPPS Y107A/F108A)
Type:
Protein
Mol. Mass.:
38479.25
Organism:
Saccharomyces cerevisiae (Yeast)
Description:
Q12051[Y107A,F108A]
Residue:
335
Sequence:
MEAKIDELINNDPVWSSQNESLISKPYNHILLKPGKNFRLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMAARAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSSHHGHSLVPFINLLGIIYQIRDDYLNLKDFQMSSEKGFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKNDNENKYLPDLASHSDTATNLHDELLYIIDHLSEL
  
Inhibitor
Name:
BDBM12578
Synonyms:
2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid | Bisphosphonate 3 | CGP-42446 | CHEMBL924 | JMC515594 Compound 55 | Reclast | US11279719, Example Zolendronic acid (ZOL) | ZOL | Zoledronate | Zometa | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl]phosphonic acid | zoledronic acid
Type:
Small organic molecule
Emp. Form.:
C5H10N2O7P2
Mol. Mass.:
272.0896
SMILES:
OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
Structure:
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