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Target
Interleukin-10
Ligand
BDBM192718
Substrate
n/a
Meas. Tech.
AlphaLISA-based IL-10 Detection
EC50
>10000±n/a nM
Citation
 Sundberg, TB; Liang, Y; Wu, H; Choi, HG; Kim, ND; Sim, T; Johannessen, L; Petrone, A; Khor, B; Graham, DB; Latorre, IJ; Phillips, AJ; Schreiber, SL; Perez, J; Shamji, AF; Gray, NS; Xavier, RJ Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo. ACS Chem Biol 11:2105-11 (2016) [PubMed]  Article 
Target
Name:
Interleukin-10
Synonyms:
IL10 | IL10_HUMAN | Interleukin-10 (IL-10)
Type:
Protein
Mol. Mass.:
20520.59
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
178
Sequence:
MHSSALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRN
  
Inhibitor
Name:
BDBM192718
Synonyms:
HG-9-91-01 derivative, 7
Type:
Small organic molecule
Emp. Form.:
C35H41N7O3
Mol. Mass.:
607.7451
SMILES:
COc1ccc(nc1)N1C(=O)N(Cc2cnc(Nc3ccc(cc3OC(C)C)C3CCN(C)CC3)nc12)c1c(C)cccc1C
Structure:
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