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TargetIRE1α
LigandBDBM192754
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
pH7.5±n/a
IC50 9.2e+2± 0 nM
Commentsextracted
Citation Feldman, HCTong, MWang, LMeza-Acevedo, RGobillot, TALebedev, IGliedt, MJHari, SBMitra, AKBackes, BJPapa, FRSeeliger, MAMaly, DJ Structural and Functional Analysis of the Allosteric Inhibition of IRE1a with ATP-Competitive Ligands. ACS Chem Biol11:2195-205 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
IRE1α
Name:IRE1α
Synonyms:n/a
Type:Protein
Mol. Mass.:49232.75
Organism:Homo sapiens (Human)
Description:Cytosolic kinase and RNase domains of human IRE1α (residues 547-977) in SF9 insect cells
Residue:431
Sequence:
GSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECF
SFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPI
TLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFS
RRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANIL
LGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVS
DRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRN
KKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHEPP
EPQPPVTPDAL
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  Blast E-value cutoff:
BDBM192754
NameBDBM192754
Synonyms:PRT062607
TypeSmall organic molecule
Emp. Form.C19H23N9O
Mol. Mass.393.4456
SMILESN[C@H]1CCCCC1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2nccn2)n1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a