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Target
Presenilin-1
Ligand
BDBM193064
Substrate
n/a
Meas. Tech.
Cell-Based Assay
Temperature
310.15±n/a K
IC50
15±n/a nM
Comments
extracted
Citation
 Pettersson, MY; Johnson, DS; Subramanyam, C; O'Donnell, CJ; am Ende, CW; Green, ME; Patel, NC; Stiff, CM; Tran, TP; Kauffman, GW; Stepan, AF; Verhoest, PR Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders US Patent  US9193726 Publication Date 11/24/2015 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM193064
Synonyms:
US9193726, 52
Type:
Small organic molecule
Emp. Form.:
C26H27F3N4O4
Mol. Mass.:
516.5122
SMILES:
COc1cc(ccc1[C@H]1CC[C@H](O1)[C@H](C)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O)C(F)(F)F
Structure:
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