Reaction Details Report a problem with these data
Target
Lysosomal protective protein [29-480]
Ligand
BDBM193540
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
5.5±n/a
Temperature
298.15±n/a K
IC50
2426±n/a nM
Comments
extracted
Citation
 Ruf, S; Sadowski, T; Wirth, K; Schreuder, H; Buning, C; Kallus, C; Strobel, H; Wehlan, H Biaryl-propionic acid derivatives and their use as pharmaceuticals US Patent  US9199947 Publication Date 12/1/2015 
Target
Name:
Lysosomal protective protein [29-480]
Synonyms:
CTSA | Cathepsin A | Cathepsin A (CTSA) | PPGB | PPGB_HUMAN
Type:
n/a
Mol. Mass.:
51408.15
Organism:
Homo sapiens (Human)
Description:
P10619[29-480]
Residue:
452
Sequence:
APDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY
  
Inhibitor
Name:
BDBM193540
Synonyms:
US9199947, 33
Type:
Small organic molecule
Emp. Form.:
C25H20FNO3S
Mol. Mass.:
433.495
SMILES:
OC(=O)CC(c1nccs1)c1cccc(c1)-c1ccc(OCc2ccccc2)c(F)c1
Structure:
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