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TargetBromodomain-containing protein 4 (BRD4)
LigandBDBM193892
Substrate/Competitorn/a
Meas. Tech.BRD4-BD1 Binding Assay
Temperature298.15±n/a K
IC50 5e+2± 26 nM
Commentsextracted
Citation Yang, YZhao, LXu, BYang, LZhang, JZhang, HZhou, J Design, synthesis and biological evaluation of dihydroquinoxalinone derivatives as BRD4 inhibitors. Bioorg Chem68:236-44 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bromodomain-containing protein 4 (BRD4)
Name:Bromodomain-containing protein 4 (BRD4)
Synonyms:BET bromodomain 4(1) (BRD4(1)) | BRD4-BD1 protein (aa 44-168) | Bromodomain protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 bromodomain 1 (BRD4-BD1)
Type:Enzyme Catalytic Domain
Mol. Mass.:14866.49
Organism:Homo sapiens (Human)
Description:aa (44-168)
Residue:125
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKT
PMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINE
LPTEE
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BDBM193892
NameBDBM193892
Synonyms:4-(4-Chlorobenzyl)-6-(3,5-dimethylisoxazol-4-yl)-3,4-dihydroquinoxalin-2(1H)-one (5k)
TypeSmall organic molecule
Emp. Form.C20H18ClN3O2
Mol. Mass.367.829
SMILESCc1noc(C)c1-c1ccc2NC(=O)CN(Cc3ccc(Cl)cc3)c2c1
Structure
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