Reaction Details
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Hypoxanthine-guanine-xanthine phosphoribosyltransferase
Ligand
BDBM60884
Substrate
n/a
Meas. Tech.
Growth Inhibition Assay
Temperature
310.15±n/a K
Ki
>200000±n/a nM
Comments
extracted
Citation
De Jersey, J; Guddat, LW; Hockova, D; Keough, DT 6-oxopurine phosphoribosyltransferase inhibitors US Patent US9200020 Publication Date 12/1/2015 More Info.:
Target
Name:
Hypoxanthine-guanine-xanthine phosphoribosyltransferase
Synonyms:
HGXR_PLAFG | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) | Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT) | LACZ
Type:
Protein
Mol. Mass.:
26352.14
Organism:
Plasmodium falciparum
Description:
P20035
Residue:
231
Sequence:
MPIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYDIKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQSTGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKATSL
Inhibitor
Name:
BDBM60884
Synonyms:
US9200020, Table 1, Compound 2B
Type:
n/a
Emp. Form.:
C9H15N5O4P
Mol. Mass.:
288.2203
SMILES:
OP(O)(=O)CCNCCn1c[nH]c2c1nc[nH]c2=O
Structure:
