Reaction Details Report a problem with these data
Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM194493
Substrate
n/a
Meas. Tech.
Spectrophotometric Assay
pH
7.4±n/a
Ki
500±100 nM
Comments
extracted
Citation
 De Jersey, J; Guddat, LW; Hockova, D; Keough, DT 6-oxopurine phosphoribosyltransferase inhibitors US Patent  US9200020 Publication Date 12/1/2015 
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:
Protein
Mol. Mass.:
24579.61
Organism:
Homo sapiens (Human)
Description:
P00492
Residue:
218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
  
Inhibitor
Name:
BDBM194493
Synonyms:
US9200020, Table 3 compound 2
Type:
Small organic molecule
Emp. Form.:
C13H22N6O6P
Mol. Mass.:
389.3241
SMILES:
COC(=O)CCN(CCn1c[nH]c2c1nc(N)[nH]c2=O)CCP(O)(O)=O
Structure:
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