Reaction Details
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Hypoxanthine phosphoribosyltransferase
Ligand
BDBM194499
Substrate
n/a
Meas. Tech.
Spectrophotometric Assay
pH
7.4±n/a
Ki
50±4 nM
Comments
extracted
Citation
De Jersey, J; Guddat, LW; Hockova, D; Keough, DT 6-oxopurine phosphoribosyltransferase inhibitors US Patent US9200020 Publication Date 12/1/2015 More Info.:
Target
Name:
Hypoxanthine phosphoribosyltransferase
Synonyms:
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:
Enzyme
Mol. Mass.:
26972.31
Organism:
Plasmodium vivax
Description:
A0A0J9TE27
Residue:
233
Sequence:
MKIPNNPGAGENALEPIYIKDDDGYDIDTFLIPDHYKNYITKVLIPNGVLKNRIEKLAFDIKQVYRNEEFHVICLLKGSRGFFSALLKYLNRIHNYSSTESPKHLYVEHYVRVKSYCNDQSLDRIEIVSEDLSCLKDKHVLIVEDIIDTGKTLLKFCEYLKKFEVKTIAITCLFIKRTPLWNGFKADFVGFSIPDAFVVGYSLDYNEKFRDLDHLCLVNDEGIKKFRTAPPTA
Inhibitor
Name:
BDBM194499
Synonyms:
US9200020, Table 3 compound 8
Type:
Small organic molecule
Emp. Form.:
C12H20N6O6P
Mol. Mass.:
375.2976
SMILES:
Nc1nc2n(CCN(CCC(O)=O)CCP(O)(O)=O)c[nH]c2c(=O)[nH]1
Structure:
