Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Hypoxanthine-guanine-xanthine phosphoribosyltransferase
Ligand
BDBM60887
Substrate
n/a
Meas. Tech.
Growth Inhibition Assay
Temperature
310.15±n/a K
Ki
100±30 nM
Comments
extracted
Citation
De Jersey, J; Guddat, LW; Hockova, D; Keough, DT 6-oxopurine phosphoribosyltransferase inhibitors US Patent US9200020 Publication Date 12/1/2015 More Info.:
Target
Name:
Hypoxanthine-guanine-xanthine phosphoribosyltransferase
Synonyms:
HGXR_PLAFG | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) | Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT) | LACZ
Type:
Protein
Mol. Mass.:
26352.14
Organism:
Plasmodium falciparum
Description:
P20035
Residue:
231
Sequence:
MPIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYDIKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQSTGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKATSL
Inhibitor
Name:
BDBM60887
Synonyms:
US9200020, Table 3, Compound 2B
Type:
n/a
Emp. Form.:
C13H21N5O6P
Mol. Mass.:
374.3095
SMILES:
COC(=O)CCN(CCn1c[nH]c2c1nc[nH]c2=O)CCP(O)(O)=O
Structure:
