Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 4
Ligand
BDBM194515
Substrate
n/a
Meas. Tech.
Competitive Binding Assay
IC50
<100±n/a nM
Citation
 Natchus, MG; Arrendale, R; Liotta, D Tricyclic amino containing compounds for treatment or prevention of symptoms associated with endocrine dysfunction US Patent  US9205085 Publication Date 12/8/2015 
Target
Name:
C-X-C chemokine receptor type 4
Synonyms:
C-X-C chemokine receptor type 4 | C-X-C chemokine receptor type 4 (CXCR4/SDF-1) | CXCR4_RAT | Cmkar4 | Cxcr4
Type:
Enzyme
Mol. Mass.:
39342.13
Organism:
Rattus norvegicus (Rat)
Description:
O08565
Residue:
349
Sequence:
MEIYTSDNYSEEVGSGDYDSNKEPCFRDENENFNRIFLPTIYFIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAMADWYFGKFLCKAVHIIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKAVYVGVWIPALLLTIPDIIFADVSQGDGRYICDRLYPDSLWMVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYVGISIDSFILLEVIKQGCEFESVVHKWISITEALAFFHCCLNPILYAFLGAKFKSSAQHALNSMSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
  
Inhibitor
Name:
BDBM194515
Synonyms:
US9205085, MSX- 168
Type:
Small organic molecule
Emp. Form.:
C22H24N2
Mol. Mass.:
316.4394
SMILES:
C(NCc1ccc(CNCc2ccccc2)cc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: