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TargetC-X-C chemokine receptor type 4 (CXCR4/SDF-1)
LigandBDBM194521
Substrate/Competitorn/a
Meas. Tech.Competitive Binding Assay
IC50 1±n/a nM
Citation Natchus, MGArrendale, RLiotta, D Tricyclic amino containing compounds for treatment or prevention of symptoms associated with endocrine dysfunction US Patent US9205085 Publication Date 12/8/2015
More Info.:Get all data from this article,  Assay Method
 
C-X-C chemokine receptor type 4 (CXCR4/SDF-1)
Name:C-X-C chemokine receptor type 4 (CXCR4/SDF-1)
Synonyms:C-X-C chemokine receptor type 4
Type:Enzyme
Mol. Mass.:39342.13
Organism:Rattus norvegicus (Rat)
Description:O08565
Residue:349
Sequence:
MEIYTSDNYSEEVGSGDYDSNKEPCFRDENENFNRIFLPTIYFIIFLTGIVGNGLVILVM
GYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAMADWYFGKFLCKAVHIIYTVNLYSS
VLILAFISLDRYLAIVHATNSQSARKLLAEKAVYVGVWIPALLLTIPDIIFADVSQGDGR
YICDRLYPDSLWMVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVI
LILAFFACWLPYYVGISIDSFILLEVIKQGCEFESVVHKWISITEALAFFHCCLNPILYA
FLGAKFKSSAQHALNSMSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM194521
NameBDBM194521
Synonyms:US9205085, MSX- 205
TypeSmall organic molecule
Emp. Form.C22H24N2O2
Mol. Mass.348.4382
SMILESCOc1cccc(NCc2ccc(CNc3cccc(OC)c3)cc2)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a