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TargetBeta-secretase 1 (1-458 aa)
LigandBDBM113273
Substrate/Competitorn/a
Meas. Tech.BACE Enzyme Assay (Ex.434)
pH4.5±n/a
Temperature298.15±n/a K
IC50 465.8±n/a nM
Commentsextracted
Citation Cacatian, SClaremon, DADillard, LWFuchs, KHeine, NJia, LLeftheris, KMcKeever, BMorales-Ramos, ASingh, SBVenkatraman, SWu, GWu, ZXu, ZYuan, JZheng, Y Inhibitors of beta-secretase US Patent US9212153 Publication Date 12/15/2015
More Info.:Get all data from this article,  Assay Method
 
Beta-secretase 1 (1-458 aa)
Name:Beta-secretase 1 (1-458 aa)
Synonyms:n/a
Type:n/a
Mol. Mass.:50753.53
Organism:Homo sapiens (Human)
Description:Truncation 1-458 aa with His-tag at C-terminus
Residue:458
Sequence:
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTI
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  Blast E-value cutoff:
BDBM113273
NameBDBM113273
Synonyms:US8633212, 51 | US9212153, 51
TypeSmall organic molecule
Emp. Form.C22H22N4O2
Mol. Mass.374.4357
SMILESCN1OC2(N=C1N)c1cc(ccc1CC21CCOCC1)-c1cccc(c1)C#N |c:4|
Structure
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n/a