Target
Polyphenol oxidase 1 [61-568]
Ligand
BDBM195550
Substrate
BDBM60928
Meas. Tech.
Tyrosinase Activity Assay
pH
6.8±n/a
IC50
785± 64 nM
Comments
extracted
Citation
 Tang, JLiu, JWu, F Molecular docking studies and biological evaluation of 1,3,4-thiadiazole derivatives bearing Schiff base moieties as tyrosinase inhibitors. Bioorg Chem 69:29-36 (2016) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 1 [61-568]
Synonyms:
PPO1 | PPO1_AGABI | Polyphenol oxidase | Tyrosinase
Type:
Protein
Mol. Mass.:
57193.31
Organism:
Agaricus bisporus (Mushroom)
Description:
Q00024[61-568]
Residue:
508
Sequence:
LIPFDDAVGPTEFSPFDQWTGYCTHGSTLFPTWHRPYVLILEQILSGHAQQIADTYTVNKSEWKKAATEFRHPYWDWASNSVPPPEVISLPKVTITTPNGQKTSVANPLMRYTFNSVNDGGFYGPYNQWDTTLRQPDSTGVNAKDNVNRLKSVLKNAQASLTRATYDMFNRVTTWPHFSSHTPASGGSTSNSIEAIHDNIHVLVGGNGHMSDPSVAPFDPIFFLHHANVDRLIALWSAIRYDVWTSPGDAQFGTYTLRYKQSVDESTDLAPWWKTQNEYWKSNELRSTESLGYTYPEFVGLDMYNKDAVNKTISRKVAQLYGPQRGGQRSLVEDLSNSHARRSQRPAKRSRLGQLLKGLFSDWSAQIKFNRHEVGQSFSVCLFLGNVPEDPREWLVSPNLVGARHAFVRSVKTDHVAEEIGFIPINQWIAEHTGLPSFAVDLVKPLLAQGLQWRVLLADGTPAELDSLEVTILEVPSELTDDEPNPRSRPPRYHKDITHGKRGGCREA
  
Inhibitor
Name:
BDBM195550
Synonyms:
2-(((5-Mercapto-1,3,4-thiadiazol-2-yl)imino)methyl)phenol (12)
Type:
Small organic molecule
Emp. Form.:
C9H7N3OS2
Mol. Mass.:
237.301
SMILES:
Oc1ccccc1C=Nc1nnc(S)s1 |w:7.7|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM60928
Synonyms:
BDBM50130192 | L-3,4-dihydroxyphenylalanine | L-DOPA | US11021454, Compound L-dopa | dihydroxyphenylalanine
Type:
n/a
Emp. Form.:
C9H11NO4
Mol. Mass.:
197.1879
SMILES:
N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: