Reaction Details Report a problem with these data
Target
Liver carboxylesterase 1
Ligand
BDBM195570
Substrate
n/a
Meas. Tech.
Gel-based ABPP (CES1)
pH
7.5±n/a
IC50
<5±n/a nM
Comments
extracted
Citation
Ahn, K; Boehm, M; Brown, MF; Calloway, J; Che, Y; Chen, J; Fennell, KF; Geoghegan, KF; Gilbert, AM; Gutierrez, JA; Kalgutkar, AS; Lanba, A; Limberakis, C; Magee, TV; O'Doherty, I; Oliver, R; Pabst, B; Pandit, J; Parris, K; Pfefferkorn, JA; Rolph, TP; Patel, R; Schuff, B; Shanmugasundaram, V; Starr, JT; Varghese, AH; Vera, NB; Vernochet, C; Yan, J Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism. ACS Chem Biol 11:2529-40 (2016) [PubMed] Article
More Info.:
Target
Name:
Liver carboxylesterase 1
Synonyms:
Acyl coenzyme A:cholesterol acyltransferase | Acyl-CoA: cholesterol acyltransferase (ACAT) | CES1 | CES2 | EST1_HUMAN | SES1 | Serine hydrolase (CES1)
Type:
Protein
Mol. Mass.:
62520.83
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
567
Sequence:
MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIPMQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLKDKEVAFWTNLFAKKAVEKPPQTEHIEL