Reaction Details Report a problem with these data
Target
Histone deacetylase 6 [440-798]
Ligand
BDBM198123
Substrate
n/a
Meas. Tech.
HDAC6 fluorescence anisotropy assay
Temperature
298.15±n/a K
Ki
800±100 nM
IC50
1400±200 nM
Comments
extracted
Citation
 Hai, Y; University of Pennsylvania,, DW Histone deacetylase 6 structure and molecular basis of catalysis and inhibition Nat Chem Biol 12:741-747 (2016) [PubMed]  Article 
Target
Name:
Histone deacetylase 6 [440-798]
Synonyms:
Catalytic domain 2 (zCD2) | zCD2
Type:
n/a
Mol. Mass.:
39850.25
Organism:
Danio rerio
Description:
F8W4B7[440-798]
Residue:
359
Sequence:
SSPITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLR
  
Inhibitor
Name:
BDBM198123
Synonyms:
Trifluoroketone
Type:
Small organic molecule
Emp. Form.:
C3H3F3O
Mol. Mass.:
112.0505
SMILES:
CC(=O)C(F)(F)F
Structure:
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