Reaction Details Report a problem with these data
Target
D-amino-acid oxidase
Ligand
BDBM50431067
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
1.4±n/a nM
Comments
extracted
Citation
 Hondo, T; Nakanishi, K; Niimi, T; Warizaya, M; Namatame, I; Harada, K Dihydroxy aromatic heterocyclic compound US Patent  US9212147 Publication Date 12/15/2015 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
  
Inhibitor
Name:
BDBM50431067
Synonyms:
CHEMBL2338797 | US10202399, Example 18 | US10463663, Example 6 | US11129828, Example 6 | US9212147, 18 | US9290456, 6 | US9931340, Example 6
Type:
Small organic molecule
Emp. Form.:
C12H11FN2O2
Mol. Mass.:
234.2263
SMILES:
Oc1cc(CCc2cccc(F)c2)n[nH]c1=O
Structure:
Search PDB for entries with ligand similarity: