Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Nitric oxide synthase oxygenase [E25A,E26A,E316A]
Ligand
BDBM50379204
Substrate
n/a
Meas. Tech.
bBiDomain assay
IC50
3.66e+4±n/a nM
Citation
Holden, JK; Lewis, MC; Cinelli, MA; Abdullatif, Z; Pensa, AV; Silverman, RB; Poulos, TL Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors. Biochemistry 55:5587-5594 (2016) [PubMed] Article More Info.:
Target
Name:
Nitric oxide synthase oxygenase [E25A,E26A,E316A]
Synonyms:
NOSO_BACSU | Nitric Oxide Synthase | bNOS | nos | yflM
Type:
n/a
Mol. Mass.:
41721.58
Organism:
Bacillus subtilis
Description:
5G65
Residue:
363
Sequence:
MEEKEILWNEAKAFIAACYQELGKAAEVKDRLADIKSEIDLTGSYVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATNNGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGWRGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPIISDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLWKDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQAEEAGRKLTGDWTWLIPPISPAATHIFHRSYDNSIVKPNYFYQDKPYE
Inhibitor
Name:
BDBM50379204
Synonyms:
4-Methylquinolin-2-amine | CHEMBL2011275
Type:
Small organic molecule
Emp. Form.:
C10H10N2
Mol. Mass.:
158.1998
SMILES:
Cc1cc(N)nc2ccccc12
Structure:
