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Target
Histone deacetylase 6 [25-831]
Ligand
BDBM197337
Substrate
n/a
Meas. Tech.
HDAC activity assays
IC50
9.88±1.01 nM
Citation
 Miyake, Y; Keusch, JJ; Wang, L; Saito, M; Hess, D; Wang, X; Melancon, BJ; Helquist, P; Gut, H; Matthias, P Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. Nat Chem Biol 12:748-54 (2016) [PubMed]  Article 
Target
Name:
Histone deacetylase 6 [25-831]
Synonyms:
HDAC6 (CD1-CD2)
Type:
n/a
Mol. Mass.:
89087.42
Organism:
Danio rerio (Zebrafish)
Description:
F8W4B7 25-831 aa
Residue:
807
Sequence:
KNLQEARRKGRMDRSKAEEEMSNELQNLDVQGKSKATGTGLVYVDAFTRFHCLWDASHPECPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGFCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGYNLQSTAEGVCASMRSLLGDPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQTFEGGPLSEVSPLPAPVCAEVKVSSPITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLRVNIPESLRLSLPSPKPKGKCTPGGKGKKSPRQS
  
Inhibitor
Name:
BDBM197337
Synonyms:
S-TSA
Type:
Small organic molecule
Emp. Form.:
C17H22N2O3
Mol. Mass.:
302.3682
SMILES:
C[C@@H](\C=C\C(=O)NO)\C=C(/C)C(=O)c1ccc(cc1)N(C)C |r|
Structure:
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