Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM289097
Substrate
n/a
Meas. Tech.
Human D1 Receptor Binding Assay
pH
7.4±n/a
Ki
8.54±n/a nM
Comments
extracted
Citation
Brodney, MA; Davoren, JE; Dounay, AB; Efremov, IV; Gray, DL; Green, ME; Henderson, JL; Lee, C; Mente, SR; O Neil, SV; Rogers, BN; Zhang, L Heteroaromatic compounds and their use as dopamine D1 ligands US Patent US10093655 Publication Date 10/9/2018
More Info.:
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
Inhibitor
Name:
BDBM289097
Synonyms:
(−)-1,5-Dimethyl-6-(2-methyl-4-{[3-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)pyrimidine-2,4(1H,3H)-dione (7) | US10093655, Example 7
Type:
Small organic molecule
Emp. Form.:
C19H15F3N3O3
Mol. Mass.:
390.3359
SMILES:
Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)nc(=O)n1C |(-14.73,-19.08,;-14.73,-20.62,;-16.07,-21.39,;-16.07,-22.93,;-17.4,-23.7,;-17.4,-25.24,;-16.07,-26.01,;-16.07,-27.55,;-17.4,-28.32,;-18.74,-27.55,;-18.74,-26.01,;-20.07,-25.24,;-21.4,-26.01,;-20.07,-23.7,;-20.07,-26.78,;-14.73,-23.7,;-13.4,-22.93,;-13.4,-21.39,;-12.07,-20.62,;-12.07,-19.08,;-13.4,-18.31,;-10.73,-18.31,;-10.73,-16.77,;-9.4,-19.08,;-9.4,-20.62,;-8.07,-21.39,;-10.73,-21.39,;-10.73,-22.93,)|