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TargetMatrix metalloproteinase-2 (MMP-2)
LigandBDBM199120
Substrate/Competitorn/a
Meas. Tech.enzyme-based fluorimetric assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 332.34±0.73 nM
Commentsextracted
Citation Zheng, XZZhou, JLYe, JGuo, PPLin, CS Cardioprotective effect of novel sulphonamides-1,3,5-triazine conjugates against ischaemic-reperfusion injury via selective inhibition of MMP-9. Chem Biol Drug Des88:756-765 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Matrix metalloproteinase-2 (MMP-2)
Name:Matrix metalloproteinase-2 (MMP-2)
Synonyms:72 kDa type IV collagenase
Type:n/a
Mol. Mass.:74137.51
Organism:Rattus norvegicus (Rat)
Description:P33436
Residue:662
Sequence:
MEARLVWGVLVGPLRVLCVLCCLLGHAIAAPSPIIKFPGDVSPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
KNQITYRIIGYTPDLDPETVDDAFARALKVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
GREYSSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNGDGQPCKFPFRFQGT
SYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
ESCTSAGRSDGKVWCATTTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
MAPIYTYTKNFRLSNDDIKGIQELYGPSPDADTDTGTGPTPTLGPVTPEICKQDIVFDGI
AQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGN
EYWVYSASTLERGYPKPLTSLGLPPDVQQVDAAFNWSKNKKTYIFSGDKFWRYNEVKKKM
DPGFPKLIADSWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWL
GC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM199120
NameBDBM199120
Synonyms:N-(4-(1-(4,6-bis(ethylamino)-1,3,5-triazin-2-yl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)phenyl)-4-methylbenzenesulphonamide (8b)
TypeSmall organic molecule
Emp. Form.C30H32N8O3S
Mol. Mass.584.692
SMILESCCNc1nc(NCC)nc(n1)-n1nc(cc1-c1ccc(OC)cc1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Structure
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n/a