Reaction Details Report a problem with these data
Target
72 kDa type IV collagenase
Ligand
BDBM199121
Substrate
n/a
Meas. Tech.
enzyme-based fluorimetric assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
189.38±43 nM
Comments
extracted
Citation
 Zheng, XZ; Zhou, JL; Ye, J; Guo, PP; Lin, CS Cardioprotective effect of novel sulphonamides-1,3,5-triazine conjugates against ischaemic-reperfusion injury via selective inhibition of MMP-9. Chem Biol Drug Des 88:756-765 (2016) [PubMed]  Article 
Target
Name:
72 kDa type IV collagenase
Synonyms:
72 kDa type IV collagenase | MMP2_RAT | Matrix metalloproteinase-2 (MMP-2) | Mmp2
Type:
n/a
Mol. Mass.:
74137.51
Organism:
Rattus norvegicus (Rat)
Description:
P33436
Residue:
662
Sequence:
MEARLVWGVLVGPLRVLCVLCCLLGHAIAAPSPIIKFPGDVSPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARALKVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGREYSSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNGDGQPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKVWCATTTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSNDDIKGIQELYGPSPDADTDTGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQQVDAAFNWSKNKKTYIFSGDKFWRYNEVKKKMDPGFPKLIADSWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
  
Inhibitor
Name:
BDBM199121
Synonyms:
N-(4-(1-(4,6-bis((3-aminopropyl)amino)-1,3,5-triazin-2-yl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)phenyl)-4-methylbenzenesulphonamide (8c)
Type:
Small organic molecule
Emp. Form.:
C32H38N10O3S
Mol. Mass.:
642.774
SMILES:
COc1ccc(cc1)-c1cc(nn1-c1nc(NCCCN)nc(NCCCN)n1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: