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TargetMatrix metalloproteinase-2 (MMP-2)
LigandBDBM199124
Substrate/Competitorn/a
Meas. Tech.enzyme-based fluorimetric assay
IC50 18.58±0.67 nM
Citation Zheng, XZZhou, JLYe, JGuo, PPLin, CS Cardioprotective effect of novel sulphonamides-1,3,5-triazine conjugates against ischaemic-reperfusion injury via selective inhibition of MMP-9. Chem Biol Drug Des88:756-765 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Matrix metalloproteinase-2 (MMP-2)
Name:Matrix metalloproteinase-2 (MMP-2)
Synonyms:72 kDa type IV collagenase
Type:n/a
Mol. Mass.:74137.51
Organism:Rattus norvegicus (Rat)
Description:P33436
Residue:662
Sequence:
MEARLVWGVLVGPLRVLCVLCCLLGHAIAAPSPIIKFPGDVSPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
KNQITYRIIGYTPDLDPETVDDAFARALKVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
GREYSSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNGDGQPCKFPFRFQGT
SYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
ESCTSAGRSDGKVWCATTTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
MAPIYTYTKNFRLSNDDIKGIQELYGPSPDADTDTGTGPTPTLGPVTPEICKQDIVFDGI
AQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGN
EYWVYSASTLERGYPKPLTSLGLPPDVQQVDAAFNWSKNKKTYIFSGDKFWRYNEVKKKM
DPGFPKLIADSWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWL
GC
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  Blast E-value cutoff:
BDBM199124
n/a
NameBDBM199124
Synonyms:N-(4-(1-(4,6-bis((4-methoxyphenyl)amino)-1,3,5-triazin-2-yl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)phenyl)-4-methylbenzenesulphonamide (8f)
TypeSmall organic molecule
Emp. Form.C40H36N8O5S
Mol. Mass.740.829
SMILESCOc1ccc(Nc2nc(Nc3ccc(OC)cc3)nc(n2)-n2nc(cc2-c2ccc(OC)cc2)-c2ccc(NS(=O)(=O)c3ccc(C)cc3)cc2)cc1
Structure
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