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Target
Isoform GlyT-1A of Sodium- and chloride-dependent glycine transporter 1 (GlyT-1A)
Ligand
BDBM199955
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
<10±n/a nM
Citation
 Pohlki, F; Lange, U; Amberg, W; Ochse, M; Behl, B; Hutchins, CW Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy US Patent  US9227930 Publication Date 1/5/2016 
Target
Name:
Isoform GlyT-1A of Sodium- and chloride-dependent glycine transporter 1 (GlyT-1A)
Synonyms:
Glycine Transporter 1 (GlyT1) | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 (GlyT-1A)
Type:
Protein
Mol. Mass.:
70591.43
Organism:
Homo sapiens (Human)
Description:
P48067-2
Residue:
633
Sequence:
MVGKGAKGMLNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
  
Inhibitor
Name:
BDBM199955
Synonyms:
US9227930, 202
Type:
Small organic molecule
Emp. Form.:
C25H30N4O3S
Mol. Mass.:
466.596
SMILES:
Cn1cnc(c1)S(=O)(=O)NCCOc1ccc2CC(C(Cc3ccccc3)c2c1)N1CCC1
Structure:
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