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Target
Isoform GlyT-1A of Sodium- and chloride-dependent glycine transporter 1 (GlyT-1A)
Ligand
BDBM199969
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
<10±n/a nM
Citation
 Pohlki, F; Lange, U; Amberg, W; Ochse, M; Behl, B; Hutchins, CW Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy US Patent  US9227930 Publication Date 1/5/2016 
Target
Name:
Isoform GlyT-1A of Sodium- and chloride-dependent glycine transporter 1 (GlyT-1A)
Synonyms:
Glycine Transporter 1 (GlyT1) | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 (GlyT-1A)
Type:
Protein
Mol. Mass.:
70591.43
Organism:
Homo sapiens (Human)
Description:
P48067-2
Residue:
633
Sequence:
MVGKGAKGMLNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
  
Inhibitor
Name:
BDBM199969
Synonyms:
BDBM199971 | US9227930, 209a
Type:
Small organic molecule
Emp. Form.:
C22H25FN4O2S
Mol. Mass.:
428.523
SMILES:
CNC1Cc2cc(F)c(CNS(=O)(=O)c3cn(C)cn3)cc2C1Cc1ccccc1
Structure:
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