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Target
Poly [ADP-ribose] polymerase tankyrase-2 [959-1164]
Ligand
BDBM50439804
Substrate
n/a
Meas. Tech.
Biochemical Assay
Temperature
298.15±n/a K
IC50
766±23 nM
Comments
extracted
Citation
 Cheung, AK; Chin, DN; Fan, J; Shultz, MD; Tomlinson, RC 4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors US Patent  US9227982 Publication Date 1/5/2016 
Target
Name:
Poly [ADP-ribose] polymerase tankyrase-2 [959-1164]
Synonyms:
PARP5B | TANK2 | TNKL | TNKS2 | TNKS2_HUMAN | Tankyrase 2 PARP catalytic domain (TNKS2P)
Type:
n/a
Mol. Mass.:
23526.94
Organism:
Homo sapiens (Human)
Description:
Q9H2K2[959-1164]
Residue:
206
Sequence:
SPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEGMV
  
Inhibitor
Name:
BDBM50439804
Synonyms:
CHEMBL2419693 | US9227982, 6
Type:
Small organic molecule
Emp. Form.:
C22H23N3O4S
Mol. Mass.:
425.501
SMILES:
Oc1ccccc1CCC(=O)N(Cc1cccs1)Cc1nc2CCOCc2c(=O)[nH]1
Structure:
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