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TargetAldose reductase L301M (AR)
LigandBDBM16312
Substrate/Competitorn/a
Meas. Tech.IC50-Activity Assay (AR)
pH7±n/a
IC50 5.0e+2± 0 nM
Commentsextracted
Citation Cousido-Siah, ARuiz, FXFranflík, JGiménez-Dejoz, JMitschler, AKamlar, MVesely´, JAjani, HParés, XFarrés, JHobza, PPodjarny, AD IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors ACS Chem Biol11:2693-2705 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aldose reductase L301M (AR)
Name:Aldose reductase L301M (AR)
Synonyms:n/a
Type:Protein
Mol. Mass.:35873.53
Organism:Homo sapiens (Human)
Description:P15121 with one mutation L301M. 2PDK
Residue:316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
MLSCTSHKDYPFHEEF
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BDBM16312
NameBDBM16312
Synonyms:(4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-imidazolidine]-2',5'-dione | CHEMBL266497 | Sorbinil
TypeSmall organic molecule
Emp. Form.C11H9FN2O3
Mol. Mass.236.1992
SMILESFc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1 |r|
Structure
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n/a