Target
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Ligand
BDBM289552
Substrate
n/a
Meas. Tech.
IMAP TR-FRET assay
Temperature
298.15±n/a K
EC50
<100±n/a nM
Comments
extracted
Citation
 Branstetter, BBreitenbucher, JDyck, BGomez, LHudson, ARMarrone, TJPeters, MVickers, T Substituted thiophene- and furan-fused azolopyrimidine-5-(6H)-one compounds US Patent  US10092575 Publication Date 10/9/2018 
Target
Name:
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Synonyms:
63 kDa Cam-PDE | Calcium/calmodulin-dependent 3 ,5 -cyclic nucleotide phosphodiesterase 1B | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Cam-PDE 1B | PDE1B | PDE1B1 | PDE1B_HUMAN | PDES1B | Phosphodiesterase 1B | Phosphodiesterase 1B (PDE1B1) | Phosphodiesterase Type 1 (PDE1B) | Phosphodiesterase, PDE1/PDE5
Type:
Enzyme
Mol. Mass.:
61366.51
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
536
Sequence:
MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNLEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD
  
Inhibitor
Name:
BDBM289552
Synonyms:
7-((6-(4-Methoxybenzyl)-5-oxo-5,6-dihydrothieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-8-yl)methyl)tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one | US10092575, Example 40 | US10376514, Example 40
Type:
Small organic molecule
Emp. Form.:
C22H22N6O4S
Mol. Mass.:
466.513
SMILES:
COc1ccc(Cn2c3sc(CN4CCN5C(COC5=O)C4)cc3c3ncnn3c2=O)cc1
Structure:
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