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Target
RAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E]
Ligand
BDBM202851
Substrate
n/a
Meas. Tech.
In Vitro Enzyme Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
0.039±n/a nM
Comments
extracted
Citation
 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Biaryl amide compounds as kinase inhibitors US Patent  US9242969 Publication Date 1/26/2016 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E]
Synonyms:
C-RAF | Proto-oncogene C-Raf (C-Raf FL) | RAF | RAF proto-oncogene serine/threonine-protein kinase | RAF1 | RAF1_HUMAN
Type:
n/a
Mol. Mass.:
73012.38
Organism:
Homo sapiens (Human)
Description:
P04049[Y340E,Y341E]
Residue:
648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSEEWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM202851
Synonyms:
US10245267, Example 829 | US10709712, Example 204 | US9242969, 204 | US9694016, 829
Type:
Small organic molecule
Emp. Form.:
C25H21F3N4O2S
Mol. Mass.:
498.52
SMILES:
Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1nc(N2CCOCC2)c2sccc2n1
Structure:
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