Target
RAF proto-oncogene serine/threonine-protein kinase [1-324]
Ligand
BDBM202663
Substrate
n/a
Meas. Tech.
In Vitro Enzyme Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
0.899±n/a nM
Comments
extracted
Citation
 Barsanti, PABurger, MLou, YNishiguchi, GPolyakov, VRamurthy, SRico, ASetti, LSmith, ATaft, BTanner, HDiPesa, AYusuff, N Biaryl amide compounds as kinase inhibitors US Patent  US9242969 Publication Date 1/26/2016 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase [1-324]
Synonyms:
C-Raf TR (aa 1-324) | Proto-oncogene C-Raf (C-Raf TR) | RAF | RAF1 | RAF1_HUMAN
Type:
n/a
Mol. Mass.:
36996.69
Organism:
Homo sapiens (Human)
Description:
P04049 (1-324)
Residue:
324
Sequence:
QEKNKIRPRGQRDSSEEWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM202663
Synonyms:
US10709712, Example 8 | US9242969, 8 | US9242969, 9 | US9694016, 8
Type:
Small organic molecule
Emp. Form.:
C27H28F3N5O4S
Mol. Mass.:
575.603
SMILES:
Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)N1CCS(=O)(=O)CC1)N1CCOCC1
Structure:
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