Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM202953
Substrate
n/a
Meas. Tech.
In Vitro Assay: Intracellular Calcium Measurements
Temperature
310.15±n/a K
IC50
1±n/a nM
Comments
extracted
Citation
 Aissaoui, HBoss, CBrotschi, CHeidmann, BSifferlen, TWilliams, JT Lactam derivatives useful as orexin receptor antagonists US Patent  US9242970 Publication Date 1/26/2016 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM202953
Synonyms:
US9242970, 100
Type:
Small organic molecule
Emp. Form.:
C25H28N2O3S
Mol. Mass.:
436.566
SMILES:
COc1cccc(OC)c1C1CCCCC(=O)N1Cc1cccc(c1)-c1ncc(C)s1
Structure:
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