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Target
Kallikrein-7 [37-253,Y180R]
Ligand
BDBM203864
Substrate
n/a
Meas. Tech.
Human KLK7 Fluorescence-Lifetime Assay
pH
5.6±n/a
Temperature
298.15±n/a K
IC50
7e+2± 2e+2 nM
Comments
extracted
Citation
 Maibaum, J; Liao, SM; Vulpetti, A; Ostermann, N; Randl, S; Rüdisser, S; Lorthiois, E; Erbel, P; Kinzel, B; Kolb, FA; Barbieri, S; Wagner, J; Durand, C; Fettis, K; Dussauge, S; Hughes, N; Delgado, O; Hommel, U; Gould, T; Mac Sweeney, A; Gerhartz, B; Cumin, F; Flohr, S; Schubart, A; Jaffee, B; Harrison, R; Risitano, AM; Eder, J; Anderson, K Small-molecule factor D inhibitors targeting the alternative complement pathway. Nat Chem Biol 12:1105-1110 (2016) [PubMed]  Article 
Target
Name:
Kallikrein-7 [37-253,Y180R]
Synonyms:
KLK7 | KLK7_HUMAN | Kalligrein-7 Y180R (KLK7) | PRSS6 | SCCE
Type:
Protein
Mol. Mass.:
23785.70
Organism:
Homo sapiens (Human)
Description:
P49862 (37-253 aa with Y180R mutation)
Residue:
217
Sequence:
ARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVRKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM203864
Synonyms:
(S)-N2-(4-methoxyphenethyl)-N1-(naphthalen-1-ylmethyl)pyrrolidine-1,2-dicarboxamide (1)
Type:
Small organic molecule
Emp. Form.:
C26H29N3O3
Mol. Mass.:
431.5268
SMILES:
COc1ccc(CCNC(=O)[C@@H]2CCCN2C(=O)NCc2cccc3ccccc23)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: