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TargetMyeloid cell leukemia 1 (Mcl-1)
LigandBDBM203873
Substrate/Competitorn/a
Meas. Tech.TR-FRET Binding A
Ki 44±0 nM
IC50 162±23 nM
Citation Akçay, GBelmonte, MAAquila, BChuaqui, CHird, AWLamb, MLRawlins, PBSu, NTentarelli, SGrimster, NPSu, Q Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain. Nat Chem Biol12:931-936 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Myeloid cell leukemia 1 (Mcl-1)
Name:Myeloid cell leukemia 1 (Mcl-1)
Synonyms:n/a
Type:n/a
Mol. Mass.:17896.13
Organism:Homo sapiens (Human)
Description:n/a
Residue:157
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQG
MLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPL
AESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
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BDBM203873
n/a
NameBDBM203873
Synonyms:7-(3-((4-Boronophenoxy)methyl)-1,5-dimethyl-1H-pyrazol-4-yl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid, 9 | Mcl-1 inhibitor 9
TypeSmall organic molecule
Emp. Form.C34H38BN3O6
Mol. Mass.595.493
SMILESCC1C(C(COc2ccc(cc2)B(O)O)NN1C)c1cccc2C(CCCOc3cccc4ccccc34)C(Nc12)C(O)=O
Structure
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