Reaction Details Report a problem with these data
Target
Bcl-2-like protein 1 [1-209]
Ligand
BDBM156390
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
pH
7.5±n/a
IC50
15±n/a nM
Comments
extracted
Citation
 Diebold, RB; Gero, TW; Grover, P; Huang, S; Ioannidis, S; Ogoe, CA; Saeh, JC Chemical compounds US Patent  US9248140 Publication Date 2/2/2016 
Target
Name:
Bcl-2-like protein 1 [1-209]
Synonyms:
Apoptosis regulator Bcl-XL | B2CL1_HUMAN | BCL2L | BCL2L1 | BCLX
Type:
Protein
Mol. Mass.:
23354.38
Organism:
Homo sapiens (Human)
Description:
C-terminal 6XHIS tagged Bcl-XL (aa 1-209)
Residue:
209
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQER
  
Inhibitor
Name:
BDBM156390
Synonyms:
US9018381, 13 | US9248140, 13
Type:
Small organic molecule
Emp. Form.:
C48H54ClF3N6O6S3
Mol. Mass.:
999.622
SMILES:
N[C@H](C1CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN2CCN(CCO)CC2)CSc2ccccc2)c(c1)S(=O)(=O)C(F)(F)F)c1ccccc1-c1ccc(Cl)cc1 |r|
Structure:
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