Reaction Details Report a problem with these data
Target
Endothelial lipase
Ligand
BDBM205033
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
8±n/a
Temperature
310.15±n/a K
IC50
3.255±n/a nM
Comments
extracted
Citation
 Abell, L; Adam, L; Cavallaro, CL; Finlay, H; Friends, TJ; Hangeland, JJ; Jiang, J; Lawrence, RM; Qiao, JX; Hu, CH; Wang, TC Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors US Patent  US9249096 Publication Date 2/2/2016 
Target
Name:
Endothelial lipase
Synonyms:
EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG
Type:
Protein
Mol. Mass.:
56805.62
Organism:
Homo sapiens (Human)
Description:
Q9Y5X9
Residue:
500
Sequence:
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP
  
Inhibitor
Name:
BDBM205033
Synonyms:
US9249096, 46
Type:
Small organic molecule
Emp. Form.:
C18H22Cl2N2O3
Mol. Mass.:
385.285
SMILES:
CCCCN1CC(C(=O)NCCCc2ccc(Cl)c(Cl)c2)=C(O)C1=O |t:21|
Structure:
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