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Target
Bromodomain-containing protein 2 [71-194,348-455]
Ligand
BDBM205453
Substrate
n/a
Meas. Tech.
Bromodomains Assay for DiscoveRx Gene Symbol
Ki
0.024±0.0 nM
Citation
 Tanaka, M; Roberts, JM; Seo, HS; Souza, A; Paulk, J; Scott, TG; DeAngelo, SL; Dhe-Paganon, S; Bradner, JE Design and characterization of bivalent BET inhibitors. Nat Chem Biol 12:1089-1096 (2016) [PubMed]  Article 
Target
Name:
Bromodomain-containing protein 2 [71-194,348-455]
Synonyms:
BET bromodomain 2(1,2) (BRD2(1,2)) | BRD2 | BRD2_HUMAN | KIAA9001 | RING3
Type:
n/a
Mol. Mass.:
27418.07
Organism:
Homo sapiens (Human)
Description:
P25440 (BRD2, 71-194 and 348-455)
Residue:
232
Sequence:
KPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPD
  
Inhibitor
Name:
BDBM205453
Synonyms:
MTI (35)
Type:
Small organic molecule
Emp. Form.:
C54H66Cl2N10O9S2
Mol. Mass.:
1134.199
SMILES:
Cc1sc-2c(c1C)C(=NC(CC(=O)NCCOCCOCCOCCOCCOCCOCCOCCNC(=O)C[C@@H]1N=C(c3c(C)c(C)sc3-n3c(C)nnc13)c1ccc(Cl)cc1)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8,43|
Structure:
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