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Target
Probable manganese-dependent inorganic pyrophosphatase
Ligand
BDBM205473
Substrate
n/a
Meas. Tech.
Colorimetric Malachite Green Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
9.7e+4± 1.6e+4 nM
Comments
extracted
Citation
 Pang, AH; Garzan, A; Larsen, MJ; McQuade, TJ; Garneau-Tsodikova, S; Tsodikov, OV Discovery of Allosteric and Selective Inhibitors of Inorganic Pyrophosphatase from Mycobacterium tuberculosis. ACS Chem Biol 11:3084-3092 (2016) [PubMed]  Article 
Target
Name:
Probable manganese-dependent inorganic pyrophosphatase
Synonyms:
Inorganic pyrophosphatase (SaPPiase) | PPAC_STAAR | ppaC
Type:
Protein
Mol. Mass.:
34052.80
Organism:
Staphylococcus aureus (Firmicutes)
Description:
Q6GFD7
Residue:
309
Sequence:
MAKTYIFGHKNPDTDAISSAIIMAEFEQLRGNSGAKAYRLGDVSAETQFALDTFNVPAPELLTDDLDGQDVILVDHNEFQQSSDTIASATIKHVIDHHRIANFETAGPLCYRAEPVGCTATILYKMFRERGFEIKPEIAGLMLSAIISDSLLFKSPTCTQQDVKAAEELKDIAKVDIQKYGLDMLKAGASTTDKSVEFLLNMDAKSFTMGDYVTRIAQVNAVDLDEVLNRKEDLEKEMLAVSAQEKYDLFVLVVTDIINSDSKILVVGAEKDKVGEAFNVQLEDDMAFLSGVVSRKKQIVPQITEALTK
  
Inhibitor
Name:
BDBM205473
Synonyms:
PPiase inhibitor, 17
Type:
Small organic molecule
Emp. Form.:
C30H44N6
Mol. Mass.:
488.7106
SMILES:
CCCCN(CCCC)c1nc(nc(n1)-c1cccn1CCCc1ccccc1)N1CCCCCC1
Structure:
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