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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM206306
Substrate
n/a
Meas. Tech.
In vitro MAO-A/B Inhibition Assay
IC50
2.87e+5± 1.47e+4 nM
Citation
 Jia, WZ; Cheng, F; Zhang, YJ; Ge, JY; Yao, SQ; Zhu, Q Rapid synthesis of flavone-based monoamine oxidase (MAO) inhibitors targeting two active sites using click chemistry. Chem Biol Drug Des 89:141-151 (2017) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM206306
Synonyms:
3-(1-((2-(4-chlorophenyl)-4-oxo-4H-chromen-6-yl)methyl)-1H-1,2,3-triazol-4-yl)-N-(p-tolyl)propanamide (Az2k5)
Type:
Small organic molecule
Emp. Form.:
C28H23ClN4O3
Mol. Mass.:
498.96
SMILES:
Cc1ccc(NC(=O)CCc2cn(Cc3ccc4oc(cc(=O)c4c3)-c3ccc(Cl)cc3)nn2)cc1
Structure:
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