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Target
Mitogen-activated protein kinase 1
Ligand
BDBM120102
Substrate
n/a
Meas. Tech.
ERK-2 Enzymatic Assay
pH
7.3±n/a
IC50
3.3±n/a nM
Comments
extracted
Citation
 Blake, JF; Chicarelli, MJ; Garrey, RF; Gaudino, J; Grina, J; Moreno, DA; Mohr, PJ; Ren, L; Schwarz, J; Chen, H; Robarge, K; Zhou, A Serine/threonine kinase inhibitors US Patent  US9259470 Publication Date 2/16/2016 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM120102
Synonyms:
US8697715, 68 | US9259470, 68
Type:
Small organic molecule
Emp. Form.:
C23H24ClFN4O3
Mol. Mass.:
458.913
SMILES:
Cc1cc(cc(=O)n1[C@H](CO)c1ccc(Cl)c(F)c1)-c1ccnc(NC2CCOCC2)n1 |r|
Structure:
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