Reaction Details Report a problem with these data
Target
Casein kinase I isoform epsilon
Ligand
BDBM206985
Substrate
n/a
Meas. Tech.
In Vitro ATP-33P Casein Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
7±n/a nM
Comments
extracted
Citation
 Cote-Des-Combes, S; Froissant, J; Gibert, J; Marguet, F; Pacaud, C; Puech, F; Ravet, A 3,4-dihydropyrrolo[1,2-A]pyrazine-2,8(1H)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof for diseases involving casein kinase 1 epsilon and/or casein kinase 1 delta US Patent  US9233965 Publication Date 1/12/2016 
Target
Name:
Casein kinase I isoform epsilon
Synonyms:
Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Ɛ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN
Type:
Protein
Mol. Mass.:
47340.25
Organism:
Homo sapiens (Human)
Description:
P49674
Residue:
416
Sequence:
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
  
Inhibitor
Name:
BDBM206985
Synonyms:
US9233965, 53
Type:
Small organic molecule
Emp. Form.:
C29H36N4O3
Mol. Mass.:
488.6211
SMILES:
COc1ccc(cc1)-c1c(C(N)=O)c2CN(CCn2c1C1CC1)C(=O)NCC12CC3CC1CC(C2)C3 |TLB:30:29:34:31.32,THB:30:31:34:29.28.35,32:31:28:33.34.35,32:33:28:31.30|
Structure:
Search PDB for entries with ligand similarity: