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TargetAcyl-protein thioesterase 1 (APT1 Q83P)
LigandBDBM207992
Substrate/Competitorn/a
Meas. Tech.Steady-State Kinetic Assays
pH6.5±n/a
Ki>10000±0.0 nM
Commentsextracted
Citation Won, SJDavda, DLabby, KJHwang, SYPricer, RMajmudar, JDArmacost, KARodriguez, LARodriguez, CLChong, FSTorossian, KAPalakurthi, JHur, ESMeagher, JLBrooks, CLStuckey, JAMartin, BR Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2). ACS Chem Biol11:3374-3382 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Acyl-protein thioesterase 1 (APT1 Q83P)
Name:Acyl-protein thioesterase 1 (APT1 Q83P)
Synonyms:n/a
Type:Protein
Mol. Mass.:24639.32
Organism:Homo sapiens (Human)
Description:Human APT1 with Q83P mutation
Residue:230
Sequence:
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRP
VTLNMNVAMPSWFDIIGLSPDSPEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQ
GGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLM
FGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM207992
NameBDBM207992
Synonyms:ML349
TypeSmall organic molecule
Emp. Form.C23H22N2O4S2
Mol. Mass.454.562
SMILESCOc1ccc(cc1)N1CCN(CC1)C(=O)c1cc2CS(=O)(=O)c3ccccc3-c2s1
Structure
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n/a