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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM208499
Substrate
n/a
Meas. Tech.
Antagonistic Activity Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
16.9±n/a nM
Comments
extracted
Citation
 Futamura, A; Araki, Y; Abe, M; Ohta, H; Suzuki, R; Nozawa, D Heteroaromatic methyl cyclic amine derivative US Patent  US9266870 Publication Date 2/23/2016 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM208499
Synonyms:
US9266870, 15
Type:
Small organic molecule
Emp. Form.:
C23H19FN6O2
Mol. Mass.:
430.4344
SMILES:
Fc1ccc(nc1)-c1ccn(CC2OCCN2C(=O)c2ccccc2-c2ncccn2)n1 |w:12.12|
Structure:
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