Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM208486
Substrate
n/a
Meas. Tech.
Antagonistic Activity Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
18.6±n/a nM
Comments
extracted
Citation
 Futamura, A; Araki, Y; Abe, M; Ohta, H; Suzuki, R; Nozawa, D Heteroaromatic methyl cyclic amine derivative US Patent  US9266870 Publication Date 2/23/2016 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM208486
Synonyms:
US9266870, 2
Type:
Small organic molecule
Emp. Form.:
C22H20FN7O2
Mol. Mass.:
433.4383
SMILES:
Cc1ccc(c(c1)C(=O)N1CCOC1Cn1cc(cn1)-c1ccc(F)cn1)-n1nccn1
Structure:
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