Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM208510
Substrate
n/a
Meas. Tech.
Antagonistic Activity Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
59.1±n/a nM
Comments
extracted
Citation
 Futamura, A; Araki, Y; Abe, M; Ohta, H; Suzuki, R; Nozawa, D Heteroaromatic methyl cyclic amine derivative US Patent  US9266870 Publication Date 2/23/2016 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM208510
Synonyms:
US9266870, 26
Type:
Small organic molecule
Emp. Form.:
C24H21FN6O3
Mol. Mass.:
460.4603
SMILES:
Cc1ccc(-c2ncccn2)c(c1)C(=O)N1CCCOC1Cc1noc(n1)-c1ccc(F)cn1 |w:20.23|
Structure:
Search PDB for entries with ligand similarity: