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Target
Bcl-2-like protein 1
Ligand
BDBM209230
Substrate
n/a
Meas. Tech.
FL5.12 Cellular Assay
EC50
10±n/a nM
Citation
 Wang, L; Doherty, G; Wang, X; Tao, Z; Bruncko, M; Kunzer, AR; Wendt, MD; Song, X; Frey, R; Hansen, TM; Sullivan, GM; Judd, A; Souers, A Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases US Patent  US9266877 Publication Date 2/23/2016 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Apoptosis regulator Bcl-XL | B2CL1_MOUSE | Bcl2l | Bcl2l1 | Bclx
Type:
Protein
Mol. Mass.:
26122.63
Organism:
Mus musculus (Mouse)
Description:
Q64373
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEETEAERETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIASWMATYLNDHLEPWIQENGGWDTFVDLYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM209230
Synonyms:
US9266877, 176
Type:
Small organic molecule
Emp. Form.:
C38H39N7O3S
Mol. Mass.:
673.826
SMILES:
CN(C)C1(Cn2c(C)c(cc2C#N)-c2ccc(nc2C(O)=O)N2CCc3cccc(C(=O)Nc4nc5ccccc5s4)c3C2)CCCCC1
Structure:
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